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Immunogen
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Prelamin A C-terminus peptide
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Specificity
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Anti prelamin A polyclonal antibody detects fulllength prelamin A which has not yet undergone to proteolytic steps, both in its nonfarnesylated and in its farnesylated form. The farnesylated form of fulllength prelamin A is labelled by antibody with lower efficiency. The antibody does not cross react with mature lamin A.
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Characteristics
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Several laminopathies are characterized by anomalous accumulation of prelamin A. This polyclonal antibody is able to detect full-lenght prelamin A, while it does not recognize either mature lamin A or cleaved prelamin A intermediates.
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Purification
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Polyclonal immunoglobulins purified by protein A affinity chromatography and stabilized with 5% of glycerol.
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