產(chǎn)品詳情

  • 產(chǎn)品名稱：SNX-482

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：BioLeaf
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
SNX-482
詳情介紹：
Sequence GVDKAGCRYM FGGCSVNDDC CPRLGCHSLF SYCAWDLTFS D.
Specificity SNX-482 blocks R-type (Cav2.3) and P/Q-type voltage-gated Ca2+ channels2.
Characteristics Source: Hysterocrates gigas (African tarantula).
Molecular formula: C192H274N52O60S7.
Disulfide bonds between Cys7-Cys21, Cys14-Cys26, and Cys20-Cys33.
Purity > 98 %
Molecular Weight 4495
Application Notes 10-100 nM
Comment

-theraphotoxin-Hg1a, -TRTX-Hg1a
Restrictions For Research Use only
Format Lyophilized
Reconstitution Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Concentration after reconstitution: Dissolving 50g in 1.112ml will provide a stock solution of 10 M.
Handling Advice Soluble in Water.
Product cited in: Arroyo, Aldea, Fuentealba, Albillos, García: "SNX482 selectively blocks P/Q Ca2+ channels and delays the inactivation of Na+ channels of chromaffin cells." in: European journal of pharmacology, Vol. 475, Issue 1-3, pp. 11-8, 2003 (PubMed).

Bourinet, Stotz, Spaetgens, Dayanithi, Lemos, Nargeot, Zamponi: "Interaction of SNX482 with domains III and IV inhibits activation gating of alpha(1E) (Ca(V)2.3) calcium channels." in: Biophysical journal, Vol. 81, Issue 1, pp. 79-88, 2001 (PubMed).

Newcomb, Szoke, Palma, Wang, Chen, Hopkins, Cong, Miller, Urge, Tarczy-Hornoch, Loo, Dooley, Nadasdi, Tsien, Lemos, Miljanich: "Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas." in: Biochemistry, Vol. 37, Issue 44, pp. 15353-62, 1998 (PubMed).