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  • 產品名稱：rMargatoxin(MgTX)

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rMargatoxin(MgTX)
詳情介紹：
Sequence TIINVKCTSP KQCLPPCKAQ FGQSAGAKCM NGKCKCYPH.
Specificity Margatoxin is a potent selective inhibitor of voltage-dependent potassium channels such as Kv1.3.
Characteristics Source: Centruroides margaritatus (Scorpion).
Molecular formula: C178H286N52O50S7.
Disulfide bonds between Cys7-Cys29, Cys13-Cys34, and Cys17-Cys36.
Purity > 98 %
Molecular Weight 4179
Application Notes 50pM - 50nM
Comment

K+ channel toxin -KTx 2.2
Restrictions For Research Use only
Format Lyophilized
Reconstitution Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Concentration after reconstitution: Dissolving 50g in 1.196 ml will provide a stock solution of 10 M.
Handling Advice Soluble in Water.
Supplier Images
image for rMargatoxin (MgTX) (ABIN1001644) SKCa3 channel currents, before and after application of 100nM Tamapin. The SKCa curre...
Product cited in: Garcia-Calvo, Leonard, Novick, Stevens, Schmalhofer, Kaczorowski, Garcia: "Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels." in: The Journal of biological chemistry, Vol. 268, Issue 25, pp. 18866-74, 1993 (PubMed).

Leonard, Garcia, Slaughter, Reuben: "Selective blockers of voltage-gated K+ channels depolarize human T lymphocytes: mechanism of the antiproliferative effect of charybdotoxin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 21, pp. 10094-8, 1992 (PubMed).