產(chǎn)品詳情

  • 產(chǎn)品名稱：Ac-IETD-CHO(Caspase-8/FLICEInhibitor-CHO)

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：KamiyaBiomedical
  • 產(chǎn)品文檔：
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簡單介紹：
Ac-IETD-CHO(Caspase-8/FLICEInhibitor-CHO)
詳情介紹：
Purpose Reversible caspase-8/granzyme B inhibitor?
Sequence Acetyl-Ile-Glu-Thr-Asp-CHO, Ac-IETD-CHO
Specificity Inhibits Caspase-8 and granzyme B. Inhibition of caspase-8 or granzyme B in cell extracts. Methylated peptide-FMK inhibitors (eg. Caspase -8/FLICE Inhibitor) are superior for use on live cells.
Characteristics Caspase-8/FLICE (also known as MACH or Mch5) is a member of the caspase family of cysteine proteases. Caspases play an important role in apoptosis signaling and effector mechanisms. Caspase-8 is most similar to caspase-10, both of which have "death domain" motifs. Caspase-8 appears to be physically associated with the signaling mechanism during Fas-mediated cell death and its association with Fas or tumor necrosis factor receptors via an interaction with FADD suggests it functions as an initiator rather than an effector of the cell death pathway. Thus, Caspase-8 is an upstream activator in the protease cascade that proteolytically matures other caspases.
Purity > 95 % by HPLC
Formula C21H34N4O10
Solubility DMSO
Molecular Weight 502 Da
Comment

Inhibits Caspase-8 and granzyme B. Inhibition of caspase-8 or granzyme B in cell extracts.Methylated peptide-FMK inhibitors (eg. Caspase-8/FLICE Inhibitor, Cat No. AB-004) are superior for use on live cells.
It is recommended that stock solutions be prepared in high-purity DMSO (>99.9%), and then diluted into aqueous medium. Stock solutions should not be stored.
Restrictions For Research Use only
Format Powder
Storage -20 °C