產(chǎn)品詳情

  • 產(chǎn)品名稱：LysophosphatidicAcidReceptor1(EDG2)

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  • 產(chǎn)品廠商：Exalpha
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LysophosphatidicAcidReceptor1(EDG2)
詳情介紹：
Alternative Name Lysophosphatidic Acid Receptor 1
Background Endothelial cell differentiation gene-2 (EDG2) receptor is a high affinity receptor for lysophosphatidic acid (LPA). EDG2 (LPA1), also known as lysophospholipid receptor A1, Vzg-1, mrec1.3 or GPCR26, like all other EDG receptors, couple multiple (3 or more) types of G proteins and transduce decreases in c[AMP]i through Gi and increases in [Ca2+]i by augmenting phospholipase C through Gq/11 and beta/gamma dimers and by induction of PI3 kinase, p125 FAK, phospholipase D by activating rho through G12/13. Human EDG-2 is present in high levels on oligodendrocytes and certain human malignant T cell lines. EDG2 (LPA1) receptors (with EDG4) may play a role in protecting cardiomyocytes from apoptosis induced by hypoxia and andrenergic stimulation.
Restrictions For Research Use only
Storage -80 °C