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產(chǎn)品名稱:LysophosphatidicAcidReceptor1(EDG2)
產(chǎn)品型號(hào):
產(chǎn)品廠商:Exalpha
產(chǎn)品文檔:
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簡(jiǎn)單介紹:
LysophosphatidicAcidReceptor1(EDG2)
詳情介紹:
Target details
Target details
Alternative Name
Lysophosphatidic Acid Receptor 1
Background
Endothelial cell differentiation gene-2 (EDG2) receptor is a high affinity receptor for lysophosphatidic acid (LPA). EDG2 (LPA1), also known as lysophospholipid receptor A1, Vzg-1, mrec1.3 or GPCR26, like all other EDG receptors, couple multiple (3 or more) types of G proteins and transduce decreases in c[AMP]i through Gi and increases in [Ca2+]i by augmenting phospholipase C through Gq/11 and beta/gamma dimers and by induction of PI3 kinase, p125 FAK, phospholipase D by activating rho through G12/13. Human EDG-2 is present in high levels on oligodendrocytes and certain human malignant T cell lines. EDG2 (LPA1) receptors (with EDG4) may play a role in protecting cardiomyocytes from apoptosis induced by hypoxia and andrenergic stimulation.
Application Details
Application Details
Restrictions
For Research Use only
Handling
Handling
Storage
-80 °C