產(chǎn)品詳情
所在位置: 首頁> 產(chǎn)品目錄> 試劑>

  • 產(chǎn)品名稱：AG-221(Enasidenib)

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
你添加了1件商品 查看購物車
簡單介紹：
AG-221(Enasidenib)
詳情介紹：
Purpose A potent IDH2 (Isocitrate dehydrogenase 2) inhibitor
Characteristics AG-221(Enasidenib) is a potent, selective, and reversible inhibitor of mutant IDH2 (isocitrate dehydrogenase type 2). It specifically inhibits IDH2 in the mitochondria, blocking the formation of oncometabolite 2-hydroxyglutarate (2HG). In in vitro studies, AG-221 reduces 2-HG levels by >90%, reverses histone and DNA hypermethylation, and induces cellular differentiation in leukemia cell models.
Purity ≥ 98?% by HPLC
Chemical Name 2-methyl-1-((4-(6-(trifluoromethyl)pyridin-2-yl)-6-((2-(trifluoromethyl)pyridin-4-yl)amino)-1,3,5-triazin-2-yl)amino)propan-2-ol
Formula C??H??F?N?O
Permeability Cell-permeable
Solubility DMSO (>30 mg/ml)
Molecular Weight 473.38 g/mol
CAS-No 1446502-11-9
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months