產(chǎn)品詳情
簡(jiǎn)單介紹:
AZD8055
詳情介紹:
Characteristics | A potent, ATP-competitive inhibitor of mTOR kinase (both mTORC1 and mTORC2) with an IC50of 0.8 nM. AZD8055 displays excellent selectivity (ca. 1,000-fold) against all class I PI3K isoforms and other members of the PI3K-like kinase family. In addition, it shows no significant activity against a panel of 260 kinases at concentrations up to 10 μM. AZD8055 inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphorylation of the mTORC2 substrate AKT and downstream proteins. |
Purity | ≥ 98?% by HPLC |
Chemical Name | 5-[2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol |
Formula | C??H??N?O? |
Permeability | Cell-permeable |
Molecular Weight | 465.54 g/mol |
CAS-No | 1009298-09-2 |
Restrictions | For Research Use only |
Format | Solid |
Handling Advice | Protect from air and moisture |
Storage | -20 °C |
Expiry Date | 36 months |
Supplier Images |
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