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Synonyms:
(R)-4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-morpholino-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide, Navitoclax
A potent, small molecule Bcl-2 family protein inhibitor (Ki's of <1 nm="" l="" for="" bcl-2,="" bcl-xl="" and="" bcl-w).="" displays="" anticancer="" properties.="" selectively="" binds="" to="" apoptosis="" suppressor="" proteins="" bcl-xl,="" bcl-w="" prevents="" their="" binding="" the="" apoptotic="" effectors="" bax="" bak="" proteins,="" which="" may="" trigger="" in="" tumor="" cells="" overexpressing="" bcl-w<="" p="">
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