產(chǎn)品詳情

  • 產(chǎn)品名稱：ABT-737

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
ABT-737
詳情介紹：
Purpose A small-molecule inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w.
Characteristics Crystalline solid
Molecular formular: C42H45ClN6O5S2
Purity ≥ 98?% by HPLC
Chemical Name 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide
Formula C??H??ClN?O?S?
Permeability Cell-permeable
Molecular Weight 813.43 g/mol
CAS-No 852808-04-9
Comment

Synonyms:
4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide
A small-molecule inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w. In vitro, ABT-737 binds Bcl-xL, Bcl-2 and Bcl-w with comparable high affinity, while it has over 1000-fold lower affinities for Bcl-B, Bfl-1 and Mcl-1. Displays wide range of single-agent activity against acute lymphoblastic leukemia (ALL) cell lines and xenografts
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 24 months
Supplier Images
image for ABT-737 (ABIN1888950) ABT-737