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  • 產品名稱：ETP-46464

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  • 產品廠商：Biovision
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簡單介紹：
ETP-46464
詳情介紹：
Purpose A potent ATR (ATM and Rad3-related) inhibitor
Characteristics White solid
Molecular formular: C30H22N4O2
Purity ≥ 98?% by HPLC
Chemical Name 2-Methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl)phenyl)propanenitrile; ATRi
Formula C??H??N?O?
Permeability Cell-permeable
Molecular Weight 470.52 g/mol
CAS-No 1345675-02-6
Comment

Synonyms:
2-Methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl)phenyl)propanenitrile, ATRi
A potent ATR (ATM and Rad3-related) inhibitor (IC = 25 nM). It also inhibits the activity of PI3K, mTOR and DNA-PKC with IC's of 170, 0.6 and 36 nM, respectively. ETP-46464 inhibits the restart of stalled replication forks and abrogates S phase arrest after exposure to hydroxyurea
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 24 months
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