產(chǎn)品詳情

  • 產(chǎn)品名稱：TPCA-1

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
TPCA-1
詳情介紹：
Purpose A potent and selective inhibitor of IB kinase-2 (IKK-2)
Characteristics Off-white solid
Molecular formular: C12H10FN3O2S
Purity ≥ 95?% by HPLC
Chemical Name 2-[(Aminocarbonyl)amino]-5-(4-fluor?ophenyl)-3-thiophenecarboxamide
Formula C??H??FN?O?S
Permeability Cell-permeable
Molecular Weight 279.29 g/mol
CAS-No 507475-17-4
Comment

Synonyms:
2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide
A potent and selective inhibitor of IB kinase-2 (IKK-2) (IC = 17.9 nM). Displays > 22-fold selectivity over IKK-1 and > 550-fold selectivity over other kinases and enzymes. TPCA-1 inhibits production of pro-inflammatory cytokines in vitro and in vivo and inhibits NF-B nuclear localization. It has been used to study inhibition of IKK-2 to prevent inflammatory mediator release in animal models of arthritis and airway inflammation
Restrictions For Research Use only
Format Solid
Handling Advice Protect from light and air
Storage -20 °C
Expiry Date 36 months
Supplier Images
image for TPCA-1 (ABIN1888982) TPCA-1