Comment
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Synonyms: N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl urea A highly potent inhibitor of Rho-associated kinases ROCK1 and ROCK2 (IC values: 14.5 nM for ROCK1 and 6.2 nM for ROCK2). RKI-1447 suppresses ROCK-dependent signaling, cell morphology, anchorage-independent cell growth, migration invasion and in vivo growth of mammary tumors
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