產(chǎn)品詳情

  • 產(chǎn)品名稱：KN-62

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
KN-62
詳情介紹：
Purpose KN-62 is a selective inhibitor of Ca2+/calmodulin-dependent kinase type II
Characteristics Pale yellow solid
Molecular formular: C38H35N5O6S2
Purity ≥ 98?%
Chemical Name 4-?[(2S)-?2-?[(5-?isoquinolinylsulfonyl)methylamino]-?3-?oxo-?3-?(4-?phenyl-?1-?piperazinyl)propyl]phenyl ester,? 5-?isoquinolinesulfonic acid
Formula C??H??N?O?S?
Permeability Cell-permeable
Molecular Weight 721.84 g/mol
CAS-No 127191-97-3
Comment

Synonyms:
4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester, 5-isoquinolinesulfonic acidCell-permeable.
KN-62 is a selective inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII, IC= 900 nM). It binds directly to the calmodulin of the enzyme. It does not affect the activity of several other kinases when tested at 10 μM. KN-62 also acts as a non-competitive antagonist of the purinergic receptor P2RX7 (IC = 15 nM)
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 24 months
Supplier Images
image for KN-62 (ABIN1889020) KN-62