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Comment
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Synonyms:
6-[4-(2-Piperidin-1-yl)-ethoxy)-phenyl)]-3-pyridin-4-yl- pyrazolo[1,5-a]-pyrimidine, Compound C Cell-permeable. A potent, selective , reversible and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM in the presence of 5 μM ATP and no AMP). Does not affect the activity on several structurally related kinases including JAK3, PKA, PKC, SYK and ZAPK. Also inhibits bone morphogenic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). In addition, recently Dorsomorphin has shown to induce protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway
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