產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：GSK-1120212

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：Biovision
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簡(jiǎn)單介紹：
GSK-1120212
詳情介紹：
Characteristics A potent and selective allosteric inhibitor of the MEK1 (IC50 = 0.7 nM) and MEK2 (IC50 = 0.9 nM) enzymes with potential antineoplastic activity.
Purity ≥ 98?% by HPLC
Chemical Name N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide; JTP-74057
Formula C??H??FIN?O?
Permeability Cell-permeable
Molecular Weight 615.39 g/mol
CAS-No 871700-17-3
Restrictions For Research Use only
Format Solid
Handling Advice Protect from light and air
Storage -20 °C
Expiry Date 48 months
Supplier Images
image for GSK-1120212 (ABIN809552) GSK-1120212
Product cited in: Kumar, Chou, Yee, Borzutzky, Vollmann, von Andrian, Park, Hollander, Manis, Poliani, Geha: "Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function." in: The Journal of experimental medicine, Vol. 211, Issue 5, pp. 929-42, 2014 (PubMed).