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  • 產品名稱：Nimbolide

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  • 產品廠商：Biovision
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Nimbolide
詳情介紹：
Characteristics A terpenoid lactone derived from Azadirachta indica (Neem tree) that displays a variety of biological activities including anti-malarial and anticancer activity. Recently it has also been shown that nimbolide sensitizes colon cancer cells to TRAIL-induced apoptosis through three distinct mechanisms: reactive oxygen species and ERK-mediated up-regulation of DR5 and DR4, downregulation of cell survival proteins, and up-regulation of pro-apoptotic proteins p53 and Bax.
Purity ≥ 98?% by TLC
Chemical Name (4α,5α,6α,7α,15β,17α)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic ?cid γ-lactone Methyl Ester; CCRIS 5723, NSC-309909
Formula C??H??O?
Permeability Cell-permeable
Molecular Weight 466.52 g/mol
CAS-No 25990-37-8
Research Area Kinases/Phosphatases
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months
Supplier Images
image for Nimbolide (ABIN629264) Nimbolide
Product cited in: Chitta, Paulus, Caulfield, Akhtar, Blake, Ailawadhi, Knight, Heckman, Pinkerton, Chanan-Khan: "Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenstr?ms macroglobulinemia." in: Blood cancer journal, Vol. 4, pp. e260, 2014 (PubMed).

Guswanto, Sivakumar, Rizk, Elsayed, Youssef, ElSaid, Yokoyama, Igarashi: "Evaluation of a fluorescence-based method for antibabesial drug screening." in: Antimicrobial agents and chemotherapy, Vol. 58, Issue 8, pp. 4713-7, 2014 (PubMed).

Wu, Kohli, Bergen, Cheville, Karnes, Cao, Young, Tindall, McNiven, Donkena: "Preclinical evaluation of the supercritical extract of azadirachta indica (neem) leaves in vitro and in vivo on inhibition of prostate cancer tumor growth." in: Molecular cancer therapeutics, Vol. 13, Issue 5, pp. 1067-77, 2014 (PubMed).