產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：CHIR99021

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠(chǎng)商：Biovision
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
CHIR99021
詳情介紹：
Characteristics A potent and highly selective inhibitor of glycogen synthase kinase-3beta (GSK-3beta) (IC50 = 6.7 nM). CHIR99021 has been shown to allow for long-term expansion of murine embryonic stem cells in a chemically-defined medium in conjunction with MEK/MAPK inhibitor PD184352 and fibroblast growth factor receptor (FGFR) inhibitor SU5402.
Purity ≥ 98?% by HPLC
Chemical Name 6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile; CT99022
Formula C??H??Cl?N?
Permeability Cell-permeable
Molecular Weight 465.34 g/mol
CAS-No 252917-06-9
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and moisture
Storage -20 °C
Expiry Date 24 months
Supplier Images
image for CHIR 99021 (ABIN412275) CHIR 99021
Product cited in: Pour, Pilzer, Rosner, Smith, Meissner, Nachman: "Epigenetic predisposition to reprogramming fates in somatic cells." in: EMBO reports, Vol. 16, Issue 3, pp. 370-8, 2015 (PubMed).

Gerbal-Chaloin, Dumé, Briolotti, Klieber, Raulet, Duret, Fabre, Ramos, Maurel, Daujat-Chavanieu: "The WNT/β-catenin pathway is a transcriptional regulator of CYP2E1, CYP1A2, and aryl hydrocarbon receptor gene expression in primary human hepatocytes." in: Molecular pharmacology, Vol. 86, Issue 6, pp. 624-34, 2014 (PubMed).

Zhao, Li, Trilok, Tanaka, Jokubaitis-Jameson, Wang, Niwa, Nakayama: "Small molecule-directed specification of sclerotome-like chondroprogenitors and induction of a somitic chondrogenesis program from embryonic stem cells." in: Development (Cambridge, England), Vol. 141, Issue 20, pp. 3848-58, 2014 (PubMed).

Zhou, Katsman, Dhaliwal, Davidson, Macpherson, Sakthidevi, Collura, Mitchell: "A Sox2 distal enhancer cluster regulates embryonic stem cell differentiation potential." in: Genes & development, Vol. 28, Issue 24, pp. 2699-711, 2014 (PubMed).

Abujarour, Bennett, Valamehr, Lee, Robinson, Robbins, Le, Lai, Flynn: "Myogenic differentiation of muscular dystrophy-specific induced pluripotent stem cells for use in drug discovery." in: Stem cells translational medicine, Vol. 3, Issue 2, pp. 149-60, 2014 (PubMed).