產(chǎn)品詳情

  • 產(chǎn)品名稱：Tozasertib(VX-680,MK-0457,VX6)

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
Tozasertib(VX-680,MK-0457,VX6)
詳情介紹：
Characteristics Tozasertib inhibits Aurora kinases A, B and C with Ki values of 0.6, 18 and 4.6 nM, respectively. It also inhibits Flt-3 and Abl as well as their mutant forms.
Purity ≥ 99?% by HPLC
Chemical Name MK-0457, VX6, VX-680
Formula C??H??N?OS
Permeability Cell-permeable
Molecular Weight 464.59 g/mol
CAS-No 639089-54-6
Restrictions For Research Use only
Format Solid
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 24 months
Supplier Images
image for Tozasertib (VX-680, MK-0457, VX6) (ABIN412187) Tozasertib (VX-680, MK-0457, VX6)
Product cited in: Welsbie, Yang, Ge, Mitchell, Zhou, Martin, Berlinicke, Hackler, Fuller, Fu, Cao, Han, Auld, Xue, Hirai, Germain, Simard-Bisson, Blouin, Nguyen, Davis, Enke, Boye, Merbs, Marsh-Armstrong, Hauswirth et al.: "Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 10, pp. 4045-50, 2013 (PubMed).