產(chǎn)品詳情

  • 產(chǎn)品名稱：Gefitinib

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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Gefitinib
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Characteristics Gefitinib was found to be a potent inhibitor of EGFR kinase (Ki = 0.40 nM), but much weaker against ErbB-2 kinase (Ki = 870 nM) and ErbB-4 kinase (Ki = 1.1 μM). The IC50 values for Gefitinib to inhibit HT-29 and LoV °Cell growth were 23.6 - >100 μM and 7.3 - 48.5 μM, respectively, when the exposure times are from 18 hours to 3 days. The IC50 values of Gefitinib to the breast cancer cell lines BT20, HCC1937, MDA-MB-231, BT474, and SKBR3 are 15.5+/-1.4, 8.4+/-1.5, 20.7+/-1.1, 0.25+/-0.05, 0.88+/-0.31 μM, respectively
Purity ≥ 99?% by HPLC
Chemical Name ZD-1839
Formula C??H??ClFN?O?
Permeability Cell-permeable
Molecular Weight 446.9 g/mol
CAS-No 184475-35-2
Restrictions For Research Use only
Format Solid
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 24 months
Supplier Images
image for Gefitinib (ABIN412175) Gefitinib
Product cited in: Leong, Chong, Sew, Lau, Wong, Teh, Tan, Iyer: "Targeting cancer stem cell plasticity through modulation of epidermal growth factor and insulin-like growth factor receptor signaling in head and neck squamous cell cancer." in: Stem cells translational medicine, Vol. 3, Issue 9, pp. 1055-65, 2014 (PubMed).