產(chǎn)品詳情

  • 產(chǎn)品名稱：Caspase-12InhibitorZ-ATAD-FMK

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
你添加了1件商品 查看購物車
簡單介紹：
Caspase-12InhibitorZ-ATAD-FMK
詳情介紹：
Purpose A caspase-12 inhibitor
Sequence Z-Ala-Thr-Ala-Asp(OMe)-FMK
Characteristics A synthetic peptide that irreversibly inhibits caspase-12 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Purity > 95?% by HPLC
Chemical Name Z-ATAD-FMK, Caspase-12 Inhibitor, Z-ATAD-fluoromethylketone
Formula C??H??FN?O?
Permeability Cell-permeable
Solubility DMSO
Molecular Weight 540.54 g/mol
Application Notes We recommend using up to 1000-5000X dilutions for inhibiting caspase-12 activity in cell culture (e.g., Add 1 μL to 1 mL of culture medium). The optimal doses may vary for different cells and culture conditions.
Restrictions For Research Use only
Format Liquid
Concentration 10 mM
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 12 months
Product cited in: Zeng, Li, He, Xu, Galicia, Deng, Stiles: "Adaptive basal phosphorylation of eIF2α is responsible for resistance to cellular stress-induced cell death in Pten-null hepatocytes." in: Molecular cancer research : MCR, Vol. 9, Issue 12, pp. 1708-17, 2011 (PubMed).

Bian, Elner, Elner: "Regulated expression of caspase-12 gene in human retinal pigment epithelial cells suggests its immunomodulating role." in: Investigative ophthalmology & visual science, Vol. 49, Issue 12, pp. 5593-601, 2008 (PubMed).

Fu, Minamino, Tsukamoto, Sawada, Asai, Kato, Asano, Fujita, Takashima, Hori, Kitakaze: "Overexpression of endoplasmic reticulum-resident chaperone attenuates cardiomyocyte death induced by proteasome inhibition." in: Cardiovascular research, Vol. 79, Issue 4, pp. 600-10, 2008 (PubMed).

Ou, Wu, Ip, Meng, Hsu, Ip: "Apoptosis induced by t10,c12-conjugated linoleic acid is mediated by an atypical endoplasmic reticulum stress response." in: Journal of lipid research, Vol. 49, Issue 5, pp. 985-94, 2008 (PubMed).

Trisciuoglio, Uranchimeg, Cardellina, Meragelman, Matsunaga, Fusetani, Del Bufalo, Shoemaker, Melillo: "Induction of apoptosis in human cancer cells by candidaspongiolide, a novel sponge polyketide." in: Journal of the National Cancer Institute, Vol. 100, Issue 17, pp. 1233-46, 2008 (PubMed).