產(chǎn)品詳情

  • 產(chǎn)品名稱：Cycloheximide(100mM)

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：Biovision
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Cycloheximide(100mM)
詳情介紹：
Characteristics PubChem CID: 6197
Molecular Formula: C??H??NO?
Cell Premeable: Yes
Purity > 95?%
Chemical Name 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A
Formula C??H??NO?
Permeability Cell-permeable
Background Synonyms: 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A
Molecular Weight 281.35 g/mol
CAS-No 66-81-9
Comment

A very active antibiotic against many yeasts and fungi. Inhibits protein synthesis in eukaryotes (but not in prokaryotes) by interfering with the translocation step. It inhibits chain initiation as well as chain elongation by acting on the 60S subunit of the eukaryote ribosome, interacting directly with enzyme translocase. Cycloheximide is used as an inhibitor to study cell-free protein biosynthesis in eukaryotes and also used to block ribosome-dependent in vivo polypeptide synthesis. It induces apoptosis in a variety of cells, but can also delay or inhibit apoptosis by other agents.
Restrictions For Research Use only
Format Liquid
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 6 months
Supplier Images
image for Cycloheximide (100 mM) (ABIN412360) Cycloheximide (100 mM)
Product cited in: Davydova, Ho, Malecki, Moen, Enserink, Jakobsson, Loenarz, Falnes: "Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2)." in: The Journal of biological chemistry, Vol. 289, Issue 44, pp. 30499-510, 2014 (PubMed).

Jeong, Kim, Kim, Kim, Lee, Kim, Shin: "Nonsense-mediated mRNA decay factors, UPF1 and UPF3, contribute to plant defense." in: Plant & cell physiology, Vol. 52, Issue 12, pp. 2147-56, 2011 (PubMed).

Muehlbauer, Lima, Goldman, Jacobson, Rivera, Goldberg, Palladino, Casadevall, Brojatsch: "Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin." in: The American journal of pathology, Vol. 177, Issue 2, pp. 735-43, 2010 (PubMed).