產(chǎn)品詳情

  • 產(chǎn)品名稱：Maurocalcine

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Smartox-Biotech
  • 產(chǎn)品文檔：
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簡單介紹：
Maurocalcine
詳情介紹：
Purpose Maurocalcine is a RyR channel agonist
Sequence Gly-Asp-Cys3-Leu-Pro-His-Leu-Lys-Leu-Cys10-Lys-Glu-Asn-Lys-Asp-Cys16-Cys17-Ser-Lys-Lys-Cys21-Lys-Arg-Arg-Gly-Thr-Asn-Ile-Glu-Lys-Arg-Cys32-Arg-OHDisulfid e bonds between Cys3-Cys17, Cys10-Cys21 and Cys16-Cys32
Background Maurocalcine is a component of the venom of Scorpio maurus palmatus. It folds according to an inhibitor cysteine knot. It is a new member of the family of toxins acting on ryanodine receptors with an affinity in the 10 nM range. It induces an increase in channel opening probability accompanied by sudden transitions to long lasting subconductance states. It has also been characterized as a cell penetrating peptide and its pharmacological activity can be observed upon extracellular perfusion.
Molecular Weight 3858.8 Da
Restrictions For Research Use only