產(chǎn)品詳情

  • 產(chǎn)品名稱：ShK

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：Smartox-Biotech
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
ShK
詳情介紹：
Purpose ShK is a Kv1.3 channel selective blocker
Sequence Arg-Ser-Cys3-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys12-Thr-Ala-Phe-Gln-Cys17-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys28-Arg-Lys-Thr-Cys32-Gly-Thr-Cys35-OHDisulfid e bonds between Cys3-Cys35, Cys12-Cys28 and Cys17-Cys32
Background ShK has been isolated from the venom of the Carribean seaanemone Stoichactis helianthus. This toxin inhibits voltagedependentpotassium channels. It blocks Kv1.3 (KCNA3)potently and also Kv1.1 (KCNA1), Kv1.4 (KCNA4), and Kv1.6(KCNA6) respectively with 11 pM,16 pM and 165 pM.
Molecular Weight 4054.85 Da
Restrictions For Research Use only