產(chǎn)品詳情
  • 產(chǎn)品名稱:C-646

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  • 產(chǎn)品廠商:ArborAssays
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簡單介紹:
C-646
詳情介紹:
Characteristics Orange powder
Molecular formula: C24H19N3O6
Background Synonyms:
4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl- 5-oxo-1H-pyrazol-1-yl]benzoic acid
A reversible, cell-permeable pyrazolone p300/CBP HAT inhibitor (Ki = 400 nM), which competes with acetyl-CoA for the p300 Lys-CoA binding pocket. Demonstrates 86 % inhibition against p300 at 10 nM. Less than 10 % inhibition against serotonin N-acetyltransferase, PCAF, GCN5, Rtt109, Sas, and MOZ HATs in a chemical screening assay. Treatment of C3H 10T1/2 mouse fibroblasts at 25 μM results in an inhibitory effect against basal and TSA- inducible acetylation of histones H3 and H4. Shown to inhibit human cell growth in melanoma and non-small- cell-lung cancer cell lines at 10 μM with similar or higher potency than peptide-based bisubstrate p300/CBP HAT inhibitor Lys-CoA-Tat at 25 μM.
Molecular Weight 445.4 Da
CAS-No 328968-36-1
Restrictions For Research Use only
Format Lyophilized
Reconstitution Soluble to 10 mg/mL in DMSO
Storage 4 °C