產品詳情
所在位置: 首頁> 產品目錄> 二抗>

  • 產品名稱：Rabbitanti-HumanIgM(Chainmu)Antibody

  • 產品型號：
  • 產品廠商：Acris-antibodies
  • 產品文檔：
你添加了1件商品 查看購物車
簡單介紹：
Rabbitanti-HumanIgM(Chainmu)Antibody
詳情介紹：
Immunogen Purified IgM.
Characteristics Anti-IgM antibody reacts with surface immunoglobulin IgM mu chains. IgM is one of the predominant surface immunoglobulins on B-lymphocytes. This antibody is useful when identifying lymphomas, plasmacytomas, and B-cell lineage derived Hodgkin's lymphomas. Due to the restricted expression of heavy and light chains in these diseases, demonstration of B-cell lymphomas is possible with clonal gene rearrangement studies.
Purification Purified
Background IgM normally constitutes about 10?% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to it's high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences. IgM measurement yields information about the body's immediate resistance and response to infection as well as information related to specific diseases. Decreased levels are associated with immune deficiency states, hereditary deficiencies, and myeloma. Increased levels can be associated with Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease.Synonyms: Human Immunoglobulin M
Research Area Secondary Antibodies, Immunology
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Restrictions For Research Use only
Format Liquid
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
image for Rabbit anti-Human IgM (Chain mu) Antibody (ABIN952869) Rabbit anti-Human IgM (Chain mu) antibody