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  • 產(chǎn)品名稱：anti-CD300aMolecule(CD300A)antibody(PE)

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anti-CD300aMolecule(CD300A)antibody(PE)
詳情介紹：
Immunogen HPB human acute lymphoid leukemia cell line
Clone MEM-260
Isotype IgG1
Specificity The antibody reacts with CD300a, a 60 kDa leukocyte transmembrane glycoprotein expressed on human granulocytes, monocytes, neutrophils, NK cells, mast cells and dendritic cells, 25 % of circulating T cells and 15 % of circulating B cells.
Characteristics Synonyms: CLM-8, CMRF35-H, CMRF35-H9, CMRF-35-H9, IRC1/IRC2, IRp60, CMRF35-like molecule 8,Inhibitory receptor protein 60, NK inhibitory receptor, CD300 antigen-like family member A
Purification Size-Exclusion Chromatography.
Alternative Name CD300A / CMRF35H (CD300A Antibody Abstract)
Background CD300a (CMRF-35H, IRp60) is a non-MHC-specific inhibitory receptor of immunoglobulin superfamily, which contains three immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that associate with SH2-containing phosphatases SHP-1 and SHP-2. CD300a is expressed on many cell types including T cells, NK cells, neutrophils, eosinophils or mast cells. Its triggering inhibits activating signals such as those of IL5, GM-CSF or eotaxin, as well as supresses mast cell degranulation or NK cell cytotoxic activity.Synonyms: CD300 antigen-like family member A, CLM-8, CMRF-35-H9, CMRF35-H, CMRF35-H9, CMRF35-like molecule 8, IRC1/IRC2, IRp60, Inhibitory receptor protein 60, NK inhibitory receptor
Gene ID 11314
UniProt Q9UGN4
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Application Notes Suitable for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL ofwhole blood or 10^6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 15 mM Sodium Azide as preservative and 0.2?% (w/v) high-grade BSA (Protease free) as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody in the dark at 2-8 °C. DO NOT FREEZE! Avoid prolonged exposure to light.
Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
Flow Cytometry (FACS) image for anti-CD300a Molecule (CD300A) antibody (PE) (ABIN238466) anti-CD300a Molecule (CD300A) antibody (PE)
Background publications Alvarez, Tang, Coligan, Borrego: "The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcgammaRIIa) mediated signaling." in: Molecular immunology, Vol. 45, Issue 1, pp. 253-8, 2007 (PubMed).

Dimasi, Roessle, Moran, Candiano, Svergun, Biassoni: "Molecular analysis and solution structure from small-angle X-ray scattering of the human natural killer inhibitory receptor IRp60 (CD300a)." in: International journal of biological macromolecules, Vol. 40, Issue 3, pp. 193-200, 2007 (PubMed).

Bachelet, Munitz, Levi-Schaffer: "Abrogation of allergic reactions by a bispecific antibody fragment linking IgE to CD300a." in: The Journal of allergy and clinical immunology, Vol. 117, Issue 6, pp. 1314-20, 2006 (PubMed).

Bachelet, Munitz, Moretta, Moretta, Levi-Schaffer: "The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 12, pp. 7989-95, 2005 (PubMed).

Cantoni, Bottino, Augugliaro, Morelli, Marcenaro, Castriconi, Vitale, Pende, Sivori, Millo, Biassoni, Moretta, Moretta: "Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells." in: European journal of immunology, Vol. 29, Issue 10, pp. 3148-59, 1999 (PubMed).