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  • 產(chǎn)品名稱：anti-ComplementComponent(3d/EpsteinBarrVirus)Receptor2(CR2)antibody(PE)

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  • 產(chǎn)品廠商：Acris-antibodies
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anti-ComplementComponent(3d/EpsteinBarrVirus)Receptor2(CR2)antibody(PE)
詳情介紹：
Immunogen IM9 human B-lymphoblastoid cell line.
Clone LT21
Isotype IgG1
Specificity The antibody LT21 reacts with CD21 (CR2), a 145 kDa transmembrane glycoprotein (complement C3d receptor - C3dR) expressed on B lymphocytes, follicular dendritic cells, some epithelial cells and a subsets of T lymphocytes. It is not expressed on immature B cells.
Characteristics Synonyms: Complement receptor type 2, CR2, C3DR, C3d receptor, EBV Receptor, Dendritic CellMarker, Complement C3d receptor, Epstein-Barr virus receptor
Purification Size-exclusion chromatography.
Alternative Name CD21 (CR2 Antibody Abstract)
Background CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands.Synonyms: C3DR, C3d receptor, CR2, Complement C3d receptor, Complement receptor type 2, Dendritic Cell Marker, EBV Receptor, Epstein-Barr virus receptor
UniProt P20023
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Suitable for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL ofwhole blood or 10^6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 15 mM sodium azide as preservative and 0.2?% (w/v) high-grade BSA (Protease free) as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody in the dark at 2-8 °C. Do Not Freeze! Avoid prolonged exposure to light.
Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
Flow Cytometry (FACS) image for anti-Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2) antibody (PE) (ABIN238435) anti-Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2) antibody (PE)
Background publications Suarez-Martinez, Monthioux, Ewels: "Fullerene interaction with carbon nanohorns." in: Journal of nanoscience and nanotechnology, Vol. 9, Issue 10, pp. 6144-8, 2009 (PubMed).

Singh, Blank, Shoenfeld, Illges: "Antiphospholipid syndrome patients display reduced titers of soluble CD21 in their sera irrespective of circulating anti-beta2-glycoprotein-I autoantibodies." in: Rheumatology international, Vol. 28, Issue 7, pp. 661-5, 2008 (PubMed).

Twohig, Kulik, Haluszczak, Reuter, Rossbach, Bull, Holers, Marchbank: "Defective B cell ontogeny and immune response in human complement receptor 2 (CR2, CD21) transgenic mice is partially recovered in the absence of C3." in: Molecular immunology, Vol. 44, Issue 13, pp. 3434-44, 2007 (PubMed).

Kasprzak, Spachacz, Wachowiak, Stefanska, Zabel: "Epstein-Barr virus (EBV) infection in B-cell non-Hodgkin's lymphomas in children: virus latency and its correlation with CD21 and CD23 molecules." in: Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society, Vol. 45, Issue 3, pp. 169-79, 2007 (PubMed).

Roozendaal, Carroll: "Complement receptors CD21 and CD35 in humoral immunity." in: Immunological reviews, Vol. 219, pp. 157-66, 2007 (PubMed).

Zabel, Heikenwalder, Prinz, Arrighi, Schwarz, Kranich, von Teichman, Haas, Zeller, Tedder, Weis, Aguzzi: "Stromal complement receptor CD21/35 facilitates lymphoid prion colonization and pathogenesis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 9, pp. 6144-52, 2007 (PubMed).

Faldyna, Samankova, Leva, Cerny, Oujezdska, Rehakova, Sinkora: "Cross-reactive anti-human monoclonal antibodies as a tool for B-cell identification in dogs and pigs." in: Veterinary immunology and immunopathology, Vol. 119, Issue 1-2, pp. 56-62, 2007 (PubMed).

Filatov, Krotov, Zgoda, Volkov: "Fluorescent immunoprecipitation analysis of cell surface proteins: a methodology compatible with mass-spectrometry." in: Journal of immunological methods, Vol. 319, Issue 1-2, pp. 21-33, 2007 (PubMed).