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  • 產(chǎn)品名稱：anti-MacrophageMannoseReceptor1antibody(MannoseReceptor,CType1)(FITC)

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anti-MacrophageMannoseReceptor1antibody(MannoseReceptor,CType1)(FITC)
詳情介紹：
Immunogen Chimaeric CRD4-7-Fc protein. Remarks: Spleen cells from immunised Fischer rats were fused with cells of the Y3 myeloma cell line.
Clone MR5D3
Isotype IgG2a
Specificity This antibody recognizes the Mannose Receptor, a 175 kDa type 1 membrane protein that is also known as CD206. Clone MR5D3 has been reported to be non-inhibitory for the binding of the mannose receptor to carbohydrate ligands.
Purification Affinity Chromatography on Protein G
Alternative Name CD206 / MRC1 (MRC1 Antibody Abstract)
Background CD206 is expressed on most tissue macrophages, in vitro derived dendritic cells, lymphatic and sinusoidal endothelia.Synonyms: C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, CLEC13D, CLEC13DL, MRC1L1, Macrophage mannose receptor, Macrophage mannose receptor 1-like protein 1
Gene ID 17533
NCBI Accession NP_032651
UniProt Q61830
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow cytometry: use 10 μL of neat antibody to label 10^6 cells in 100?μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS,?pH 7.4, 0.09?% Sodium Azide, 1?% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Geier, Celli: "Phagocytic receptors dictate phagosomal escape and intracellular proliferation of Francisella tularensis." in: Infection and immunity, Vol. 79, Issue 6, pp. 2204-14, 2011 (PubMed).

Hardison, Wozniak, Kolls, Wormley: "Interleukin-17 is not required for classical macrophage activation in a pulmonary mouse model of Cryptococcus neoformans infection." in: Infection and immunity, Vol. 78, Issue 12, pp. 5341-51, 2010 (PubMed).

Chavele, Martinez-Pomares, Domin, Pemberton, Haslam, Dell, Cook, Pusey, Gordon, Salama: "Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice." in: The Journal of clinical investigation, Vol. 120, Issue 5, pp. 1469-78, 2010 (PubMed).

Hardison, Ravi, Wozniak, Young, Olszewski, Wormley: "Pulmonary infection with an interferon-gamma-producing Cryptococcus neoformans strain results in classical macrophage activation and protection." in: The American journal of pathology, Vol. 176, Issue 2, pp. 774-85, 2010 (PubMed).

Dewals, Marillier, Hoving, Leeto, Schwegmann, Brombacher: "IL-4Ralpha-independent expression of mannose receptor and Ym1 by macrophages depends on their IL-10 responsiveness." in: PLoS neglected tropical diseases, Vol. 4, Issue 5, pp. e689, 2010 (PubMed).

Bacci, Capobianco, Monno, Cottone, Di Puppo, Camisa, Mariani, Brignole, Ponzoni, Ferrari, Panina-Bordignon, Manfredi, Rovere-Querini: "Macrophages are alternatively activated in patients with endometriosis and required for growth and vascularization of lesions in a mouse model of disease." in: The American journal of pathology, Vol. 175, Issue 2, pp. 547-56, 2009 (PubMed).

deSchoolmeester, Martinez-Pomares, Gordon, Else: "The mannose receptor binds Trichuris muris excretory/secretory proteins but is not essential for protective immunity." in: Immunology, Vol. 126, Issue 2, pp. 246-55, 2009 (PubMed).

Hawkes, McLaurin: "Selective targeting of perivascular macrophages for clearance of beta-amyloid in cerebral amyloid angiopathy." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 4, pp. 1261-6, 2009 (PubMed).

Devey, Ferenbach, Mohr, Sangster, Bellamy, Hughes, Wigmore: "Tissue-resident macrophages protect the liver from ischemia reperfusion injury via a heme oxygenase-1-dependent mechanism." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 17, Issue 1, pp. 65-72, 2008 (PubMed).

Hassan, Zhang, Engwerda, Kaye, Sharp, Bickle: "The Schistosoma mansoni hepatic egg granuloma provides a favorable microenvironment for sustained growth of Leishmania donovani." in: The American journal of pathology, Vol. 169, Issue 3, pp. 943-53, 2006 (PubMed).

Martinez-Pomares, Reid, Brown, Taylor, Stillion, Linehan, Zamze, Gordon, Wong: "Analysis of mannose receptor regulation by IL-4, IL-10, and proteolytic processing using novel monoclonal antibodies." in: Journal of leukocyte biology, Vol. 73, Issue 5, pp. 604-13, 2003 (PubMed).

Zamze, Martinez-Pomares, Jones, Taylor, Stillion, Gordon, Wong: "Recognition of bacterial capsular polysaccharides and lipopolysaccharides by the macrophage mannose receptor." in: The Journal of biological chemistry, Vol. 277, Issue 44, pp. 41613-23, 2002 (PubMed).