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  • 產品名稱：Orlistat

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  • 產品廠商：Biovision
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Orlistat
詳情介紹：
Characteristics

PubChem CID: 3034010
Molecular Formula: C??H??NO?
Cell Premeable: Yes

Salt form: No

Orlistat is a cell-permeable, selective, and competitive lipase inhibitor (IC?? = 0.15 μM). Targets serine hydrolases in the nervous system, such as diacylglycerol lipase (DAGL), which is responsible for the conversion of DAG to 2-AG. Partially inhibits the hydrolysis of triglycerides and lowers the absorption of dietary fat, promoting weight loss. Promotes the sensitivity to TRAIL in cancer cells by ROS-mediated pathways. Displays antiobesity and antihypercholesterolemic activity in vivo.

Smiles: CCCCCCCCCCCC(CC1C(C(=O)O1)CCCCCC)OC(=O)C(CC(C)C)NC=O

InChi: InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1

Inchi Key: AHLBNYSZXLDEJQ-FWEHEUNISA-N
Purity ≥ 98?% by HPLC
Chemical Name N-Formyl-L-leucine (1S)-1-[[(2S, 3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester; Tetrahydrolipstatin
Formula C??H??NO?
Permeability Cell-permeable
Background Synonyms: N-Formyl-L-leucine (1S)-1-[[(2S, 3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester, Tetrahydrolipstatin
Molecular Weight 495.73 g/mol
CAS-No 96829-58-2
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months