產(chǎn)品詳情

  • 產(chǎn)品名稱：Leukadherin-1

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  • 產(chǎn)品廠商：Biovision
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簡(jiǎn)單介紹：
Leukadherin-1
詳情介紹：
Characteristics A novel small molecule agonist of integrin CD11b/CD18 (also known as Mac-1). LA1 increases the extent of CD11b/CD18-dependent cell adhesion of transfected cells and of primary human and mouse neutrophils, which results in decreased chemotaxis and transendothelial migration. LA1 also decreases leukocyte recruitment and reduced arterial narrowing after injury in rats. In addition, compared to a known integrin antagonist IMB-10, LA1 better preserves kidney function in a mouse model of experimental nephritis.
Synonyms: 4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic acid, LA1
Purity ≥ 97?% by HPLC
Chemical Name 4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic acid; LA1
Formula C??H??NO?S?
Permeability Cell-permeable
Molecular Weight 421.49 g/mol
CAS-No 344897-95-6
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 24 months
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