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Background
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Omega-conotoxins act at presynaptic membranes, they bind and block voltage-sensitive calcium channels (VSCC). This peptide selectively targets N-type voltage-sensitive calcium channels. It has no effect on R-type calcium currents, voltage-sensitive sodium currents, delayed rectifier potassium currents and transient outward potassium currents. It displays an analgesic potency similar to MVIIA in a range of acute and chronic pain models in rodents, but has less adverse effects compared with identical dosages of MVIIA injected intrathecally.
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