產(chǎn)品詳情

  • 產(chǎn)品名稱：ADWX-1

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Smartox-Biotech
  • 產(chǎn)品文檔：
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簡單介紹：
ADWX-1
詳情介紹：
Purpose ADWX-1 inhibits Kv1.3 channel with an IC50 of 1.89 pM
Sequence Val-Gly-Ile-Asn-Val-Lys-Cys-Lys-His-Ser-Arg-Gln-Cys-Leu-Lys-Pro-Cys-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys-Thr-Asn-Gly-Lys-Cys-His-Cys-Thr-Pro-Lys-OH (Disulfide Bridges: Cys7-Cys27, Cys13-Cys32, Cys17-Cys34)
Background ADWX-1 is an optimised synthetic analog of the scorpion peptide BmKTx. ADWX-1 is known to block Kv1.3 channel with a high affinity (IC50 = 1.89 pM) and selectivity (340 fold higher than Kv1.1). ADWX1 appears to be an interesting therapeutic candidate to treat auto-immune disorders such as multiple sclerosis, type-1 diabetes, rheumatoid arthritis and psoriasis. This peptide is a valuable tool for studying the structure-function of Kv1.3 channel and auto-immunity mechanisms.
Molecular Weight 4071.9 Da
Restrictions For Research Use only