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  • 產品名稱：μ-conotoxinGIIIB

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μ-conotoxinGIIIB
詳情介紹：
Sequence AA sequence: Arg-Asp-Cys3-Cys4-Thr-Hyp-Hyp-Arg-Lys-Cys10 -Lys-Asp-Arg-Arg-Cys15-Lys-Hyp-Met-Lys -Cys20-Cys21-Ala-NH2 Disulfide bonds: Cys3-Cys15, Cys4-Cys20 and Cys10-Cys21
Characteristics μ-conotoxin GIIIB is a selective blocker of Nav1.4 channels
Background μ-conotoxin GIIIB is a 22-mer peptide originally isolated from the venom of the piscivorous marine snail Conus geographus. μ-conotoxin GIIIB adopts a compact structure consisting of a distorted 310-helix and a small ?-hairpin. μ-conotoxin GIIIB is stabilized by three disulphide bridges and is highly enriched in lysine and arginine residues, forming potential sites of interaction with Na channels. An unusual feature is the presence of three hydroxyproline residues. μ-conotoxin GIIIB is a useful probe to discriminate between neuronal and muscle sodium channels as it exhibits at least a 1000-fold specificity for muscle versus nerve sodium channels. μ-Conotoxin GIIIB selectively blocks Nav1.4 (μ1) voltage-dependent sodium channels, which are predominantly expressed in muscle, with an affinity close to 20 nM. μ-Conotoxin GIIIB appears to physically occlude the channel pore by binding on site I of the Na+ channel.
Molecular Weight 2640.26 kDa
CAS-No 140678-12-2
Restrictions For Research Use only
Storage -20 °C
Background publications Filatov, Rich: "Hyperpolarized shifts in the voltage dependence of fast inactivation of Nav1.4 and Nav1.5 in a rat model of critical illness myopathy." in: The Journal of physiology, Vol. 559, Issue Pt 3, pp. 813-20, 2004 (PubMed).

Li, Ennis, Vélez, Tomaselli, Marbán: "Novel structural determinants of mu-conotoxin (GIIIB) block in rat skeletal muscle (mu1) Na+ channels." in: The Journal of biological chemistry, Vol. 275, Issue 36, pp. 27551-8, 2000 (PubMed).

Cruz, Gray, Olivera, Zeikus, Kerr, Yoshikami, Moczydlowski: "Conus geographus toxins that discriminate between neuronal and muscle sodium channels." in: The Journal of biological chemistry, Vol. 260, Issue 16, pp. 9280-8, 1985 (PubMed).