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Background publications
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Robbins, Lee, Filipovich, Szigligeti, Neumeier, Petrovic, Conforti: "Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via Kv1.3 channels." in: The Journal of physiology, Vol. 564, Issue Pt 1, pp. 131-43, 2005 (PubMed).
Norton, Pennington, Wulff: "Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases." in: Current medicinal chemistry, Vol. 11, Issue 23, pp. 3041-52, 2004 (PubMed).
Middleton, Sanchez, Linde, Bugianesi, Dai, Felix, Koprak, Staruch, Bruguera, Cox, Ghosh, Hwang, Jones, Kohler, Slaughter, McManus, Kaczorowski, Garcia: "Substitution of a single residue in Stichodactyla helianthus peptide, ShK-Dap22, reveals a novel pharmacological profile." in: Biochemistry, Vol. 42, Issue 46, pp. 13698-707, 2003 (PubMed).
Lanigan, Kalman, Lefievre, Pennington, Chandy, Norton: "Mutating a critical lysine in ShK toxin alters its binding configuration in the pore-vestibule region of the voltage-gated potassium channel, Kv1.3." in: Biochemistry, Vol. 41, Issue 40, pp. 11963-71, 2002 (PubMed).
Beeton, Wulff, Barbaria, Clot-Faybesse, Pennington, Bernard, Cahalan, Chandy, Béraud: "Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 24, pp. 13942-7, 2001 (PubMed).
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